Journal :   Asian Journal of Research in Chemistry

Volume No. :   9

Issue No. :  8

Year :  2016

Pages :   369-372

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

UV Spectrophotometric Method Development and Validation of Benazepril Hydrochloride



Address:   Prajakta A. Kokane1*, Bhushan A. Bhairav1, Ravindra B. Saudagar2
1Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik.
2Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik
*Corresponding Author
DOI No: 10.5958/0974-4150.2016.00056.0

ABSTRACT:
Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. Simple, precise and accurate UV spectroscopic method has been developed and validated for estimation of Benazepril Hydrochloride. It is a angiotensin converting enzyme inhibitors. UV spectroscopic method which is based on measurement of absorption of UV light, the spectra of Benazepril Hydrochloride in methanol showed maximum wavelength at 237 nm and calibration curve were plotted over the concentrations ranging from 2-22ug/ml of Benazepril Hydrochloride with correlation coefficient 0.961 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The proposed method was validated.
KEYWORDS:
Benazepril Hydrochloride, methanol, water, Co-solvency method, spectrophotometer and validation.
Cite:
Prajakta A. Kokane, Bhushan A. Bhairav, Ravindra B. Saudagar. UV Spectrophotometric Method Development and Validation of Benazepril Hydrochloride. Asian J. Research Chem. 2016; 9(8): 369-372.
[View HTML]      [View PDF]



Visitor's No. :   204970