Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  1

Year :  2017

Pages :   54-57

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, spectral and biological studies of Cd (II) complex of Schiff base ligand derived from 3-hydrazinylquinoxalin-2(1H)-one and 2-hydroxy-3-methoxybenzaldehyde



Address:   P. Sukanya1, Ch. Venkata Ramana Reddy2*
1Vasavi College of Engineering, Hyderabad, 500031, India
2Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, -500085, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00010.4

ABSTRACT:
The Cd (II) complex of the tridentate Schiff base ligand, 3-(2-(2-hydroxy-3-methoxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (VHQO) derived from 3-hydrazinylquinoxalin-2(1H)-one and 2-hydroxy-3-methoxybenzaldehyde has been prepared and characterized by IR, UV-VIS, LCMS, CHN analysis ,thermo gravimetric analysis, magnetic susceptibility and conductivity measurements. The ligand behaved as uninegative, tridentate, N, N, O donor, coordinating to the metal ion via ring nitrogen, azomethine nitrogen and phenolic oxygen. The ligand formed a monomeric, 1:1 [Cd(VHQO)Cl] complex. The interactions between the metal complex and calf thymus DNA (CT-DNA) has been studied by absorption spectroscopy. The complex was also screened against two gram positive bacteria Staphyloccocus aureus and Bacillus subtillis, and four gram negative bacteria Escherichia coli, Pseudomonas aeroginosa, Klebsiella pneumonia and Proteus vulgaris. The results indicated moderate activity against Staphyloccocus aureus and Bacillus subtillis.
KEYWORDS:
Schiff base, Tridentate ligand, Antibacterial activity, DNA binding.
Cite:
P. Sukanya, Ch. Venkata Ramana Reddy. Synthesis, spectral and biological studies of Cd (II) complex of Schiff base ligand derived from 3-hydrazinylquinoxalin-2(1H)-one and 2-hydroxy-3-methoxybenzaldehyde. Asian J. Research Chem. 2017; 10(1):54-57.
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