Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  1

Year :  2017

Pages :   58-68

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Design, Synthesis, Structural Elucidation and Antimicrobial Screening of Novel 1, 5-Benzothiazepine derivatives Derived from Thieno [3, 2-d] Pyrimidine Nucleus



Address:   Virupakshi Prabhakar1*, Kondra Sudhakar Babu2, L.K. Ravindranath2, J. Latha3, B.Venkateswarlu4
1Faculty of Engineering Chemistry, SVR Engineering College, Jawaharlal Nehru Technological University- Ananthapuramu (JNTU-A), Nandyal, Pin 518502, Kurnool (Dist), A.P., India.
2 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (A P), India.
3Department of Environmental Science, Sri Krishnadevaraya University College of Engineering and Technology, S. K. University, Ananthapuramu – 515003 (A.P), India.
4Faculty of Engineering Chemistry, PBR VITS, Jawaharlal Nehru Technological University (JNTU-A), Kavali, Nellore (Dist), (A.P.) India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00011.6

ABSTRACT:
1, 5-Benzo Thiazepine is the Main Seven membered Heterocyclic ring systems reported for their cardiac and Psychotherapeutic activities.1,5 Benzo Thiazepines were highlighted as important Biologically active Scaffolds. In This Article New series of benzo [b] [1, 5]-thiazepine derivatives 6 a-j were synthesized by applying the cyclo condensation of (E)-3-(thieno [3, 2-d] pyrimidin-6-yl)-1-p-Substituted prop-2-en-1-one derivatives 4a-j with 2-amino thio phenol (5) in DMF. The new intermediate Chalcone derivatives 4a-j were obtained from interaction of various P-substituted Acetophenone & Heterocyclic Acetyl derivatives 3(a-j) and thieno[3,2-d]pyrimidine-7-carbaldehyde. The synthesized 1, 5-benzothiazepines 6a-j have been screened for their antimicrobial activity. From anti-bacterial and anti-fungal activity screening results, it has been observed that compounds 6h, 6e, 6i and 6d possess good activity.
KEYWORDS:
chalcones, 2-amino thio phenol, cyclisation, 1, 5-benzothiazepines, Anti-microbial activity, Thieno [3, 2-d] Pyrimidine core ring.
Cite:
Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, J. Latha, B.Venkateswarlu. Design, Synthesis, Structural Elucidation and Antimicrobial Screening of Novel 1, 5-Benzothiazepine derivatives Derived from Thieno [3, 2-d] Pyrimidine Nucleus. Asian J. Research Chem. 2017; 10(1):58-68.
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