Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  2

Year :  2017

Pages :   225-239

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review.



Address:   Arun Kumar1, Vinita Gupta2, Sanchita Singh2, Y.K. Gupta3*
1Research Scholar, School of Applied Sciences Singhania University, Pacheri Bari, Jhunjhunu (Raj.), India
2Department of Chemistry, Agra College, Agra, U.P, India
3Head Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00038.4

ABSTRACT:
The Chalcone is aromatic compounds that forms the central core for different necessity of biological compounds, and are prepared by Claisen-Schmidt condensation of equimolar concentrations of arylaldehydes and acetophenones which are generally base catalysed. Chalcones are considered as the precursors of flavonoids and isoflavonoids. as the precursors the precursors of flavonoids and isoflavonoids. Chemically, chalcones are 1,3-diaryl-2-propen-1-ones in which two aromatic rings are joined by a three carbon bridge having a carbonyl moiety and a,ß unsaturation. One of the most important classes of chalcones is the ring closure reactions with hydrazine, phenyl hydrazine, guanidine, urea etc. forming heterocyclic derivatives of chalcones. Both chalcones and their heterocyclic derivatives have a large number of pharmacological activities such as anti antimicrobial, antifungal, antibacterial, antioxidant, inflammatory, antitumor, anticancer, anti mitotic, anti leishmanial, anti-malarial, anti tubercular, antiviral, cytotoxic, etc. In this research paper (review) the efforts have been made to show some synthesis and biological activities of chalcones and their derivatives.
KEYWORDS:
Chalcones, Claisen-Schmidt condensation, Antimicrobial Activity, Heterocyclic Derivatives
Cite:
Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta. Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review. Asian J. Research Chem. 2017; 10(2):225-239.
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