Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  2

Year :  2017

Pages :   119-123

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Microwave assisted synthesis and antifungal studies of 5-amino thiadiazole substituted pyrimidine compounds



Address:   Karthic R1*, Andrews B2, Subramani K1
1PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635751, India
(Affiliated to Thiruvalluvar University, Vellore, Tamil Nadu, India)
2Department of Chemistry, Priyadarshini Engineering College, Vaniyambadi, India
(Affiliated to Anna University, Chennai, Tamil Nadu, India)
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00018.9

ABSTRACT:
Simple synthetic methods of 5-(5-amino-1,3,4-thiadiazol-2yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-thione (3f-j) are described. Compound 1 is converted to carbothiamide 2 by reacting compound 1 with thiosemicarbazide in catalytic amount of acetone is irradiated with help of domestic microwave oven (200W) for 2 minutes. Compound 2 is act as a key intermediate for the final compounds. The compound 2 is converted to corresponding thiadiazole 3 by treatment with conc.H2SO4 and NH3. Structural elucidation is accomplished by IR, 1H and 13CNMR, Elemental analysis and GC-Mass spectral data of the synthesized compounds. Few of these Pyrimidine derivatives have been evaluated for their possible antifungal activity. Most of the tested compounds show significant antifungal activity.
KEYWORDS:
Pyrimidine, thiadiazole, carbothiamide, thiosemicarbazide, antifungal activity.
Cite:
Karthic R, Andrews B, Subramani K. Microwave assisted synthesis and antifungal studies of 5-amino thiadiazole substituted pyrimidine compounds. Asian J. Research Chem. 2017; 10(2):119-123.
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