Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  2

Year :  2017

Pages :   127-130

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A non-cytotoxic pseudo peptide KL1 with potent antioxidant activity



Address:   Gangadhara MM1, Dinesha R2, Satish Kumar Murari3*
1Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore - 570 005
2Adichunchanagiri Institute for Molecular Medicine, B.G. Nagara, Mandya -571 448
3Department of Chemistry, PES college of Engineering, Mandya-571401
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00020.7

ABSTRACT:
By incorporating a reduced amide bond ? [CH2NH] into a helical antibacterial peptide, we made an attempt to synthesize an antioxidant pseudo peptide. When the pKa value of reduced amide bond is between 6.5 to7.5, it is protonated depending on the pH. We investigated the antioxidant activity by hydroxyl radical scavenging assay and DPPH radical scavenging assay, the results showed that, the antioxidant activity of KL1 pseudo peptide (51%, 56% ) were promising when compared to standard antioxidants like BHA(68%, 78%) and BHT (65%, 81% ) respectively. The cyto-toxicity studies of the pseudo peptide showed that the peptide is non-toxic to cells.
KEYWORDS:
Pseudopeptide, Reduced amide bond Selectivity, antioxidant, DPPH radical, Superoxide radical.
Cite:
Gangadhara MM, Dinesha R, Satish Kumar Murari. A non-cytotoxic pseudo peptide KL1 with potent antioxidant activity. Asian J. Research Chem. 2017; 10(2):127-130.
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