Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  3

Year :  2017

Pages :   393-398

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis, characterization and pharmacological evaluation of novel spiro heterocyclic compounds as anti diabetic agents



Address:   K. Kishore Kumar, R.S.K. Sharma, P. Chanti Babu, M. Sreenivasa Rao, K. Durga Prasadu, D. Ravi Kumar*
Department of Chemistry, CMJ University, Shillong-793101, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00067.0

ABSTRACT:
Natural products possessing a spiro carbon in their molecules have proven their biological activity in agriculture and medicine. The present paper describes the synthesis, characterization of five newly synthesized Spiro- compounds characterized by means of chromatography, IR, 1H-NMR and Mass spectral analysis. The author carried in vitro anti diabetic methods like alpha amylase and alpha glucosidase methods for anti diabetic activity of tilted compounds. The investigation of anti diabetic activity revealed that the test compounds of Spiro compounds showed favorable anti diabetic activity. Among the titled compounds some were having potent antidiabetic activity.
KEYWORDS:
Spiro heterocyclic compounds, spectral analysis, in vitro antidiabetic activity, alpha amylase enzyme method and alpha-glucosidase enzyme method.
Cite:
K. Kishore Kumar, R.S.K. Sharma, P. Chanti Babu, M. Sreenivasa Rao, K. Durga Prasadu, D. Ravi Kumar. Synthesis, characterization and pharmacological evaluation of novel spiro heterocyclic compounds as anti diabetic agents. Asian J. Research Chem. 2017; 10(3):393-398.
[View HTML]      [View PDF]



Visitor's No. :   204244