Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  3

Year :  2017

Pages :   267-270

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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An Efficient Nickel Chloride Catalyzed Multi-Component Condensation of Indole with Carbonyl Compounds in PEG-400 as a Green Medium at Ambient Conditions



Address:   Syed Nazimuddin, Maqdoom Farooqui*
Post Graduate and Research Centre, Dr. Rafiq Zakaria Campus, Maulana Azad College, Rauza Baugh, Aurangabad, 431001.
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00043.8

ABSTRACT:
Bis (indolyl) methane derivatives were efficiently synthesized by the condensation reaction of various aromatic aldehydes and indole in presence of nickel chloride as a Lewis acid catalyst in PEG-400 as a recyclable green solvent at room temperature. The use of PEG-400 and nickel chloride offers improvements for the synthesis of bis (indoyl) methanes with regard to the yield of products, short reaction times and green aspects utilizing recyclable and non volatile medium and avoiding any volatile and hazardous organic solvent.
KEYWORDS:
Bis (indolyl) methane, nicke (II) chloride, PEG-400.
Cite:
Syed Nazimuddin, Maqdoom Farooqui. An Efficient Nickel Chloride Catalyzed Multi-Component Condensation of Indole with Carbonyl Compounds in PEG-400 as a Green Medium at Ambient Conditions. Asian J. Research Chem. 2017; 10(3):267-270.
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