Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  4

Year :  2017

Pages :   486-490

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Investigation on the Binding Interaction Between Clomipramine and Doxepin with LeuT by Molecular Docking Analysis



Address:   M. Govindammal, M. Prasath*, B. Sathya, M. Selvapandiyan
Department of Physics, PG Extension Centre Periyar University, Tamilnadu, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00079.7

ABSTRACT:
Molecular docking is a computational method, has becoming an increasingly important tool for drug discovery. The drugs Clomipramine and Doxepin are selected and docked with the protein LeuT for docking analysis. Both the selected drugs are tricyclic antidepressant drugs. By using the protein Leucine Transporter the binding interactions are found for the molecule. The drug Clomipramine and Doxepin is used as a potent inhibitor of leucine transport (LeuT). LeuT is a stable, sodium-coupled Leucine transporter from the eubacteriumAquifexaeolicus. It is the only member of the neurotransmitter sodium symporter (NSS) and belongs to the family of secondary transporters. The lowest binding energy and the shortest distance between the different amino acids are resulted and tabulated. The computational method of molecular docking analysis is very interested for discovering new medicine for human health for the disease depression.
KEYWORDS:
Clomipramine, Doxepin, LeuT, tricyclic antidepressant, depression.
Cite:
M. Govindammal, M. Prasath, B. Sathya, M. Selvapandiyan. Investigation on the Binding Interaction Between Clomipramine and Doxepin with LeuT by Molecular Docking Analysis . Asian J. Research Chem. 2017; 10(4):486-490.
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