Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  4

Year :  2017

Pages :   573-576

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and antioxidant activity of some new substituted pyrazolo [4, 5-e]-4H-pyrimido[2,3-b] benzimidazoles



Address:   Prashant N. Ubale, Sambhaji P. Vartale*, Sandip G. Sontakke
PG Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya Nanded-431602 (MS), INDIA
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00095.5

ABSTRACT:
2-Amino benzimidazole condensed with ethyl-2-cyano-3,3-bis(methylthio)acrylate using catalytic amount of potassium carbonate and DMF as solvent to form 3-cyano-2-metylthio-4-oxo-4H-pyrimido [1, 2-a] benzimidazole (3). The formed compound (3) reacted with differently substituted aryl / heteryl hydrazino compounds then it gives series of substituted pyrazolo [4, 5-e]-4H-pyrimido [2, 3-b] [1, 3] benzimidazoles (5a-h). Structure of compounds were confirmed by spectroscopic techniques IR, mass, 1H &13C NMR and analytical properties. all synthesized compounds were screened for their antioxidant activity.
KEYWORDS:
Pyrazole, pyrimido benzimidazole, fused heterocycles, antioxidant activity.
Cite:
Prashant N. Ubale, Sambhaji P. Vartale, Sandip G. Sontakke. Synthesis and antioxidant activity of some new substituted pyrazolo [4, 5-e]-4H-pyrimido[2,3-b] benzimidazoles. Asian J. Research Chem. 2017; 10(4):573-576.
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