Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  4

Year :  2017

Pages :   582-586

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Molecular docking for Anti-Inflammatory and Anti Mitotic activities of (S)-(2-Methyl-4-(1-Phenyl-1h-Thieno/Furan [3, 2-C] Pyrazol-3-yl) Piperazin-1-yl)(Pyridin-2-yl) Methanone



Address:   Ramu Surakanti1, LaxminarayanaEppakayala2*, Ramchander Merugu3, Venkat Reddy Pendyala2
1Rishitha Biosciences, North Hastinapuram, LB Nagar, Hyderabad, 500 074, Telangana, India
2SreenidhiInstitute of Science and Technology (Autonomous), Ghatkesar, Hyderabad, 501301, Telangana, India
3University College of Science, Mahatma Gandhi University, Nalgonda-508254, Telangana, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00097.9

ABSTRACT:
The synthesis of piperazine derivatives containing thiophene and oxazole is described. They were prepared from (Z)-3-bromo-N'-phenylthiophene/furan-2-carbohydrazonoyl chloride in a series of steps. All the synthetic compounds are characterized by spectral analyses. They were further analyzed for anti-inflammatory and antimitotic activity and the results are discussed.
KEYWORDS:
Synthesis, anti inflammatory activity, antimitotic activity.
Cite:
Ramu Surakanti, LaxminarayanaEppakayala, Ramchander Merugu, Venkat Reddy Pendyala. Synthesis and Molecular docking for Anti-Inflammatory and Anti Mitotic activities of (S)-(2-Methyl-4-(1-Phenyl-1h-Thieno/Furan [3, 2-C] Pyrazol-3-yl) Piperazin-1-yl)(Pyridin-2-yl) Methanone. Asian J. Research Chem. 2017; 10(4):582-586.
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