Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  4

Year :  2017

Pages :   477-482

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and In Vitro Anti-inflammatory Activity of Some 1- [(2- (Methylsulphonyl amino) thiazole-4-yl) methyl]-3- aryl thioureas.



Address:   Rahul A. Waghmare*
Department of Chemistry, Milind College of Science, Nagsenvana, Aurangabad- 431 002.
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00077.3

ABSTRACT:
New thioureas (4a-f) bearing 2-methylsulhonyl amino thiazol-4-methyl moiety have been synthesized by multistep synthesis depicted in Scheme.1. Intermediate 2-Amino-4-(isothiocynatomethyl) thiazole (2) has been synthesized from 2-amino-4-chloromethyl thiazole hydrochloride (1) by nucleophilic displacement of chlorine by isothiocynate. The compound (2) on subsequent condensation with methyl sulphonyl chloride carried in the presence of triethyl amine in DCM yielded 2-methylsulphonyl amino-4-(isothiocynatomethyl) thiazole (3) which on addition with aryl amines in refluxed pyridine gave the titled thioueras. Synthesized intermediates and final compounds were characterized by I.R, 1H NMR, MASS spectroscopic techniques and C, H, N and S analysis. Synthesized final compounds were evaluated for in vitro anti-inflammatory activity by HRBC membrane stabilization method. Most of the synthesized compound exhibited good anti-inflammatory activity as compared to standard Diclofenac sodium.
KEYWORDS:
Amino-4-(isothiocynatomethyl) thiazole, aryl amine, pyridine, in vitro anti-inflammatory activity.
Cite:
Rahul A. Waghmare. Synthesis and In Vitro Anti-inflammatory Activity of Some 1- [(2- (Methylsulphonyl amino) thiazole-4-yl) methyl]-3- aryl thioureas. Asian J. Research Chem. 2017; 10(4):477-482.
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