Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  5

Year :  2017

Pages :   660-668

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Spectral, Antibacterial, Antifungal and Anticancer activity Studies of Schiff bases Derived from O-Vanillin and Aminoquinolines



Address:   S. N. Battin1, A. H. Manikshete1*, S. K. Sarasamkar2, M. R. Asabe1, D. J. Sathe3
1Department of Chemistry, Walchand College of Arts and Science, Solapur, MH, India.
2Department of Chemistry, Walchand Institute of Technology, Solapur, MH, India.
3Department of Chemistry, Kolhapur Institute of Thechnology, Kolhapur, MH, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00112.2

ABSTRACT:
In this work, five varieties of o-vanillin Schiff bases viz. 2–methoxy-6-(3/5/6/8- iminoquinolinyl methyl) phenol and 2–methoxy-6-(4-iminoquinaldinyl methyl) phenol have been synthesized with the aid of direct reflux technique in ethanol solution. The synthesized compounds were characterized through CHN evalution, UV- Visible, FTIR, 1H-NMR and Mass spectral studies. The in vitro antimicrobial activities of the synthesized Schiff bases were tested using bacterial species such as Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa and Escherichia coli. These compounds were also tested for antifungal activities against Candida albicans and Aspergillus niger. All the Schiff bases were also screened for their anticancer activities against breast cancer MCF-7 cell line and colon cancer HT-29 cell line.
KEYWORDS:
Synthesis; o-vanillin; Schiff base; spectral studies; biological activities.
Cite:
S. N. Battin, A. H. Manikshete, S. K. Sarasamkar, M. R. Asabe, D. J. Sathe. Synthesis, Spectral, Antibacterial, Antifungal and Anticancer activity Studies of Schiff bases Derived from O-Vanillin and Aminoquinolines. Asian J. Research Chem. 2017; 10(5): 660-668.
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