Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  6

Year :  2017

Pages :   771-782

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Facile One-Pot Synthesis, Characterization, and Biological Activity of 2-(5-(4-subsituted phenyl)-3-(4-subsituted phenyl)-4,5-dihydropyrazol-1-yl)-N-(5-(3-subsitutedphenyl)-1,3,4-thiadiazol-2-yl)acetamide Derivatives



Address:   ParjanyaKumar Shukla1*, Amita Verma2, Prateek Pathak2, Pragya Mishra3
1Associate Professor, Pharmaceutical chemistry, Krishnarpit Institute of Pharmacy, Allahabad, India
2Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom Institute of Agriculture, Technology & Sciences, Allahabad, India
3Centre ofFood Technology,Institute of Professional Studies,UniversityofAllahabad, Allahabad, India
*CorrespondingAuthor
DOI No: 10.5958/0974-4150.2017.00130.4

ABSTRACT:
Dihydropyrazole and 1,3,4-Thiadizole derivatives are an attractive class of biologically active heterocyclic compounds. An efficient procedure for the synthesis of Novel 2-(5-(4-bromophenyl)-3-(4-fluorophenyl)-4,5-dihydropyrazol-1-yl)-N-(5-(3 hydroxyphenyl)-1,3,4-thiadiazol-2-yl)acetamidevia one-pot threecomponent condensation of 2-hydrazinyl-N-(4-subsituted phenyl thiadiazol -2-yl) with aromatic aldehydes and substituted acetophenones is described. The structures of synthesized compounds were confirmed by analytical and spectroscopic methods including, infrared, nuclear magnetic resonance and mass spectroscopy. This protocol has advantages of mild conditions, high yield, and simple workup procedure. All the synthesized compounds were tested for their in-vitro growth inhibitory activity against a panel of standard strains of pathogenic microorganism including M. tuberculosis (H37Rv) and Gram positive bacteria (Staphylococcus aures, Bacillus subtilis and Bacilluscerus), Gram negative bacteria (Escherichia coli, Proteus vulgaris, and Pseudomonas aeruginosa) and fungal strains (Aspergillus, A. fumigates and C. albicans). Their antitubercular, antimicrobial activity study revealed that all the compounds tested showed moderate to good antitubercular, antibacterial and antifungal activity.
KEYWORDS:
Multicomponent reaction, 1,3,4-Thiadizole, Dihydropyrazole, Antitubercular activity, Antimicrobial activity, One pot synthesis.
Cite:
Parjanya Kumar Shukla, Amita Verma, Prateek Pathak, Pragya Mishra. Facile One-Pot Synthesis, Characterization, and Biological Activity of 2-(5-(4-subsituted phenyl)-3-(4-subsituted phenyl)-4,5-dihydropyrazol-1-yl)-N-(5-(3-subsitutedphenyl)-1,3,4-thiadiazol-2-yl)acetamide Derivatives. Asian J. Research Chem. 2017; 10(6):771-782.
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