Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  6

Year :  2017

Pages :   739-744

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and In Vitro Anti-inflammatory Activity of 5-arylidene-1- [(2 (Methyl suphonyl amino) thiazol-4-yl) methyl]-2-thioxoimidazolidin-4-ones.



Address:   Rahul A. Waghmare*
Department of Chemistry, Milind College of Science, Nagsenvana, Aurangabad- 431 002.
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00125.0

ABSTRACT:
One-pot multicomponent condensation carried for obtaining 5- arylidene -1- [(2-(methylsuphonyl-amino)-thiazol-4-yl)-methyl]-2-thioimidazolidin-4-ones using 2-methyl suphonyl amino-4-isothiocynato methyl thiazole, glycine and aryl aldehydes in acetic acid (Scheme1). Intermediate 2-Amino-4-(isothiocynatomethyl) thiazole (2) has been synthesized from 2-amino-4-chloromethyl thiazole hydrochloride (1) by nucleophilic displacement of chlorine with isothiocynate. Synthesized intermediates and final compounds were characterized by I.R, 1HNMR, MASS spectroscopic techniques and C, H, N and S analysis. Synthesized final compounds were evaluated for in vitro anti-inflammatory activity by HRBC membrane stabilization method. Most of the synthesized compound exhibited good anti-inflammatory activity as compared to standard Diclofenac sodium.
KEYWORDS:
2-Amino-4-(isothiocynatomethyl) thiazole, aryl aldehyde, glycine, acetic acid, in vitro anti-inflammatory activity.
Cite:
Rahul A. Waghmare. Synthesis and In Vitro Anti-inflammatory Activity of 5-arylidene-1- [(2 (Methyl suphonyl amino) thiazol-4-yl) methyl]-2-thioxoimidazolidin-4-ones. Asian J. Research Chem. 2017; 10(6):739-744.
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