Journal :   Asian Journal of Research in Chemistry

Volume No. :   10

Issue No. :  6

Year :  2017

Pages :   745-749

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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One Pot, Four-Component for the Synthesis of Pyrano Pyrazole Derivatives using TBAHS as Green Catalyst and their Biological Evaluation



Address:   Vijay N. Bhosale1* Gopinath S. Khansole2, Jaman A. Angulwar3, Sunil S. Choudhare1, Ashok R. Karad1, Navanand B. Wadwale1
1P.G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded (M.S.) India.
2Department of Chemistry, D.A.B.N. Arts & Science College, Chikhali, Sangli (M.S.) India.
3Department of Chemistry, Dayanand Science College, Latur (M.S.) India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2017.00126.2

ABSTRACT:
A green, efficient and simple procedure has been developed for the synthesis of Pyrano [2,3-c] Pyrazoles from a one pot four component condensation of ethylacetoacetate, malononitrile, hydrazine hydrate and different substituted aromatic aldehydes using Tetrabutyl ammonium hydrogen sulphate (TBAHS) as green catalyst in ethanol-water. The synthesized Pyrano [2,3-c] Pyrazoles were screened for their Antioxidant activity. These newly synthesized compounds were evaluated by their using various spectroscopic techniques and also elemental analysis.
KEYWORDS:
Pyrano pyrazoles, MCRs, TBAHS, Antioxidant activity.
Cite:
Vijay N. Bhosale, Gopinath S. Khansole, Jaman A. Angulwar, Sunil S. Choudhare, Ashok R. Karad, Navanand B. Wadwale. One Pot, Four-Component for the Synthesis of Pyrano Pyrazole Derivatives using TBAHS as Green Catalyst and their Biological Evaluation. Asian J. Research Chem. 2017; 10(6):745-749.
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