Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  1

Year :  2018

Pages :   121-125

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of glycosylated-1, 2, 4-thiadiazolidines as potent antimicrobial agents

Address:   Sneha U. Jadhao*, Shirish P. Deshmukh
Department of Chemistry, Shri Shivaji College, Akola-444001
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00025.1

A series of 4-aryl-2-?-D-glycosyl-3-oxo-5-o-tolylimino-1,2,4-thiadiazolidines have been prepared by the interaction of 1-?-D-glycosyl-3-aryl carbamides with N-o-tolyl-S-chloro isothiocarbamoyl chloride. The newly synthesized compounds have been characterized through usual chemical transformations and IR, 1H NMR and Mass spectral studies. The polarimetric study of the title compounds have been carried out. The newly synthesized compounds were screened for their in vitro antimicrobial activities using standard cup plate method. The title compounds exhibited mild to moderate antimicrobial activities.
1--D-glycosyl-3-aryl carbamides, N-o-tolyl-S-chloro isothiocarbamoyl chloride, 4-aryl-2--D-glycosyl-3-oxo-5-o-tolylimino-1, 2, 4-thiadiazolidines, in vitro antimicrobial activities.
Sneha U. Jadhao, Shirish P. Deshmukh. Synthesis of glycosylated-1, 2, 4-thiadiazolidines as potent antimicrobial agents. Asian J. Research Chem. 2018; 11(1):121-125.
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