Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  1

Year :  2018

Pages :   126-128

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Multicomponent synthesis of 2, 6-dihydro-2, 6-diimino-4, 8-bis (methylthio) pyrimido [2, 1-b] [1, 3] thiazine-3, 7-dicarbonitrile and its derivatives



Address:   Anil B. Chidrawar*
P.G. Department of Chemistry, Degloor College, Degloor, S.R.T.M.U. Nanded, Maharashtra, India - 431717
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00026.3

ABSTRACT:
Substituted derivatives of 2,6-dihydro-2,6-diimino-4,8-bis (methylthio) pyrimido[2,1-b] [1,3] thiazine-3,7-dicarbonitrile have been prepared through One Step Multicomponent reaction by heating a mixture of bis methylthio methylene malononitrile (I), thiourea (II) independently with different heteryl amines respectively in the presence of dimethyl formamide and catalytic amount of anhydrous potassium carbonate. All these newly synthesized compounds were screened for antibacterial activity and characterized by elemental analysis and spectral data.
KEYWORDS:
Bis methylthio methylene malononitrile, thiourea, heteryl amines, dimethyl formamide, K2CO3.
Cite:
Anil B. Chidrawar. Multicomponent synthesis of 2, 6-dihydro-2, 6-diimino-4, 8-bis (methylthio) pyrimido [2, 1-b] [1, 3] thiazine-3, 7-dicarbonitrile and its derivatives. Asian J. Research Chem. 2018; 11(1):126-128.
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