Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  1

Year :  2018

Pages :   139-142

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of 1, 3, 4-Oxadiazole of NSAIDs and their Biological Properties

Address:   Shankaraiah Malthum1, Venkanna Banothu2, Jaya Shree Anireddy1*
1Centre for Chemical Sciences and Technology, IST, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500085, Telangana State, India
2Center for Biotechnology, IST, JNTUH, Kukatpally, Hyderabad-500085, India
DOI No: 10.5958/0974-4150.2018.00029.9

An efficient and inexpensive approach to the synthesis of 2-substituted 1, 3, 4- oxadiazoles from arylhydrazides and orthoester is reported using catalytic PTSA. The optimized reaction is performed using catalytic PTSA in EtOH and is complete within 1 h for non aromatic orthoesters and 2-30 h for aromatic orthoesters. The reaction permits both electron releasing and electron withdrawing groups on the arylhydrazide substrate. Most products formed in high yield and require only minimal purification. The reaction proceeded smoothly and cleanly under mild reaction conditions and no side reactions were observed. The structures of the products were confirmed by IR, 1H NMR, 13C NMR, mass spectroscopy, and elemental analysis. Compared with early reports, the current reactions proceed in shorter time and require less of the orthoester.
1, 3, 4-Oxadiazole, NSAIDs, Antibacterial, Para toluene sulphonic acid.
Shankaraiah Malthum, Venkanna Banothu, Jaya Shree Anireddy. Synthesis of 1, 3, 4-Oxadiazole of NSAIDs and their Biological Properties. Asian J. Research Chem. 2018; 11(1):139-142.
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