Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  1

Year :  2018

Pages :   8-14

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis, Characterization and In-Vitro Antidiabetic Studies of Vanadium Complexes derived from N2O2 donor Ligands



Address:   Shashikant P. Pawar1, Tryambakrao J. Patil2, Ratnamala S. Bendre3*
1Smt. Narmadabai Nago Chaudhari, Arts Commerce and Science College, Kusumba, Dhule Maharashtra, India
2Jai Hind Education Trust’s Z. B. Patil College, Dhule, Maharashtra, India
3School of Chemical Sciences, North Maharashtra University Jalgaon, Maharashtra, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00003.2

ABSTRACT:
Trace elements are very essential for human health. Chemists have been attracted to prepare new potent inorganic pharmaceutical agents and these are used to treat chronic diseases. Vanadium complexes are used as good diagnostic tool for diabetes mellitus. The progress in the field of development in orally active antidiabetic vanadium complexes with different coordination structures using experimental diabetic animals and enzyme inhibitory action (a-amylase inhibition). In the present study we synthesized, characterized and evaluated % a- amylase inhibition by vanadium complexes having tetradentate Schiff base ligands–H2L1, H2L2 and H2L3. The mole ratio for preparation of complexes is 1:1. The synthesized vanadium complexes were characterized by sophisticated techniques and screened for antidiabetic activity by a-amylase inhibition assay. The data assigned to conclude that H2L1 shows lowest IC50 value 0.786 mg/ml while L2V shows highest IC50 value 0.626 mg/ml.
KEYWORDS:
Chronic diseases, antidiabetic and α-amylase Inhibition.
Cite:
Shashikant P. Pawar, Tryambakrao J. Patil, Ratnamala S. Bendre. Synthesis, Characterization and In-Vitro Antidiabetic Studies of Vanadium Complexes derived from N2O2 donor Ligands. Asian J. Research Chem. 2018; 11(1):8-14.
[View HTML]      [View PDF]



Visitor's No. :   204963