Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  1

Year :  2018

Pages :   149-152

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Some Novel Chalcone containing Pyrazole Moiety

Address:   V. A. Modhavadiya
Department of Chemistry, Shree M. M. Science college, Morbi-363642
Saurashtra University, Rajkot, Gujarat India
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00031.7

Compounds having the sulphonamide group has long been used as drugs for various diseases. The biological activity of these drugs is enhanced by complexation with metal ions. Transition metal Fe (II) complex of ligand derived from sulfamethizole and substituted p-cresol have been prepared and evaluated for antimicrobial activity. The products have been characterized by elemental analysis, IR, NMR, UV-Vis spectral studies, conductivity measurements, magnetic susceptibility measurements, molecular weight determination and stepwise stability constants by PH metric method. The elemental analysis revealed that the azo dye ligand coordinated to the metal ions in 1:2 (metal-ligand) molar ratios. The complex are non-electrolytes as confirmed by their conductivity measurements. The infrared data indicates that the ligand are coordinated with meal ions through diazo (-N=N-) nitrogen and phenolic (-OH) oxygen. The spectral data suggest distorted octahedral geometry as shown in the proposed structure.
Synthesis, Ligand, Metal Complex, Bioactivity, Characterization.
V. A. Modhavadiya. Synthesis of Some Novel Chalcone containing Pyrazole Moiety. Asian J. Research Chem. 2018; 11(1):149-152.
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