Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  1

Year :  2018

Pages :   159-165

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthesis and type- II anti-diabetic activity of Pyrrolidine-2-carbonitrile derived Ligands in SHR-STZ Animal model



Address:   Babaso V. Udugade1*, Shivaji P. Gawade2
1Department of Medicinal Chemistry, Satara College of Pharmacy, Degaon, Satara- 415004 Maharashtra India
2Department of Pharmacology, Sahyadri College of Pharmacy, Methawade, Sangola- 413307, Maharashtra, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00033.0

ABSTRACT:
We reported the synthesis and type- II anti-diabetic activity of pyrrolidine-2-carbonitrile derived ligands in SHR-STZ animal models. 3 Dimensional Quantitative Structural activity, pharmacophore, docking studies used for design of molecules, studies reveled that novel substituted cyanopyrrolidines had been promising candidate for further research. Molecules had been synthesized and evaluated for anti-diabetic activity through the use of Spontaneously Hypertensive Rat- Streptozotocin animal model. Amongst all of the synthesized compounds 1-(2-(5- methylisoxazol-3-ylamino) acetyl) pyrrolidine-2-carbonitrile, 1- (2-(5-methyl-1, 2, 4-oxadiazol-3-ylamino) acetyl) pyrrolidine-2- carbonitrile and 1-(2-(1, 2, 4-thiadiazol-5- ylamino) acetyl) pyrrolidine-2-carbonitrile had been found to be strong anti-diabetic activity.
KEYWORDS:
Design, Synthesis, Pyrrolidine- 2-carbonitrile, Anti-diabetic ligands and SHR-STZ animal model.
Cite:
Babaso V. Udugade, Shivaji P. Gawade. Synthesis and type- II anti-diabetic activity of Pyrrolidine-2-carbonitrile derived Ligands in SHR-STZ Animal model. Asian J. Research Chem. 2018; 11(1):159-165.
[View HTML]      [View PDF]



Visitor's No. :   203644