Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  1

Year :  2018

Pages :   166-170

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Preparation and Characterization of Flurbiprofen Co-crystals By Using Factorial Design



Address:   Zalte A. G.*, Saudagar R. B.
R. G. Sapkal College of Pharmacy, Anjaneri, Nashik.
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00034.2

ABSTRACT:
Flurbiprofen is a non-steroidal anti-inflammatory BCS class II drug of low solubility and high permeability. Pharmaceutical co-crystals of Flurbiprofen were prepared with co-crystal former as benzoic acid to improve drug its physicochemical parameters. Solvent drop grinding method was found to be successful to prepare Flurbiprofen co-crystals. All new crystalline forms were characterized by IR spectroscopy, differential scanning calorimetry, and X-ray diffraction to confirm their purity and homogeneity. Co-crystals with benzoic acid showed a faster powder dissolution rate as compared with pure active pharmaceutical ingredient (API). Co-crystals of Flurbiprofen with benzoic acid showed increase in solubility by 6.68 fold as compared with pure active pharmaceutical ingredient (API). The study showed that co-crystals is an emerging alternative to modify and enhance physicochemical properties of drug to enhance their pharmaceutical properties.
KEYWORDS:
Flurbiprofen Co-crystals, Co-crystals, Cocrystallisation, Flurbiprofen.
Cite:
Zalte A. G., Saudagar R. B.. Preparation and Characterization of Flurbiprofen Co-crystals By Using Factorial Design. Asian J. Research Chem. 2018; 11(1):166-170.
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