Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  2

Year :  2018

Pages :   385-390

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Evaluation of Anti microbial Activity of Substituted 1, 4-bis (5- phenyl isoxazole-3-yl) benzene derivatives



Address:   Karri Apparao1, Tentu Nageswararao1*, N. Krishnarao1, S. Cinyya Setty2, T. Prsanna Devi3
1Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, India
2Research and Development Centre, Pharma zel, Visakhapatnam, Andhra Pradesh, India
3Department of Chemistry, Viswabharati College, Visakhapatnam, Andhra Pradesh, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00069.X

ABSTRACT:
The preliminary investigation of newly synthesized , evaluated and the bioevaluation of 1,4-bis (5- phenyl isoxazole-3-yl) benzene which was obtained from the cyclization of 3,3’-(1,4-phenylene) bis (1-phenyl prop-2-en-1-one) treated with hydroxyl amine hydrochloride in the presence of ethanol. The 3, 3’-(1,4-phenylene) bis (1-phenyl prop-2-en-1-one can be synthesized from the condensation of the terepthaldehyde and substituted aryl, alkyl ketones in the presence of potassium tertiarybutaxide. All the newly synthesized compounds were evaluated by advanced spectroscopic analysis (1HNMR, 13CNMR) and also structural determination was calculated by elemental analysis. The titled compounds were screened by the antimicrobial activity.
KEYWORDS:
1, 4-bis (5- phenyl isoxazole-3-yl) benzene, Anti microbial Activity, NMR.
Cite:
Karri Apparao, Tentu Nageswararao, N. Krishnarao, S. Cinyya Setty, T. Prsanna Devi. Synthesis and Evaluation of Anti microbial Activity of Substituted 1, 4-bis (5- phenyl isoxazole-3-yl) benzene derivatives. Asian J. Research Chem. 2018; 11(2):385-390.
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