Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  2

Year :  2018

Pages :   236-240

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Some New N-Mannich Bases Derivatives of Phenytoin



Address:   Sushil R. Mathapati1, Vikas B. Suryawanshi2,Abhay S. Bondge3,Jairaj K. Dawale4*
1Department of Chemistry, S. M. P. Mahavidyalaya, Murum-413605, Dist.- Osmanabad, India.
2Department of Chemistry, KMC College, Khopoli, Maharashtra- 410203 India.
3Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra- -413544, India.
4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH- 413521, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00044.5

ABSTRACT:
5,5-Diphenylhydantoin (Phenytoin) is a well-known anticonvulsant and antiarrhythmic drug which may cause unwanted side effects. In order to avoid the adverse effects of phenytoin, especially on the central nervous and cardiovascular systems, a small series of amine derivatives (Mannich bases) were designed containing phenytoin nucleus. For this synthesis we follow green methodology during synthesis of phenytoin from benzyl and urea.
KEYWORDS:
Phenytoin, Mannich bases, Green methods, Benzyl.
Cite:
Sushil R. Mathapati, Vikas B. Suryawanshi,Abhay S. Bondge,Jairaj K. Dawale. Synthesis of Some New N-Mannich Bases Derivatives of Phenytoin. Asian J. Research Chem. 2018; 11(2):236-240.
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