Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  2

Year :  2018

Pages :   236-240

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Some New N-Mannich Bases Derivatives of Phenytoin

Address:   Sushil R. Mathapati1, Vikas B. Suryawanshi2,Abhay S. Bondge3,Jairaj K. Dawale4*
1Department of Chemistry, S. M. P. Mahavidyalaya, Murum-413605, Dist.- Osmanabad, India.
2Department of Chemistry, KMC College, Khopoli, Maharashtra- 410203 India.
3Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra- -413544, India.
4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH- 413521, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00044.5

5,5-Diphenylhydantoin (Phenytoin) is a well-known anticonvulsant and antiarrhythmic drug which may cause unwanted side effects. In order to avoid the adverse effects of phenytoin, especially on the central nervous and cardiovascular systems, a small series of amine derivatives (Mannich bases) were designed containing phenytoin nucleus. For this synthesis we follow green methodology during synthesis of phenytoin from benzyl and urea.
Phenytoin, Mannich bases, Green methods, Benzyl.
Sushil R. Mathapati, Vikas B. Suryawanshi,Abhay S. Bondge,Jairaj K. Dawale. Synthesis of Some New N-Mannich Bases Derivatives of Phenytoin. Asian J. Research Chem. 2018; 11(2):236-240.
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