Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  2

Year :  2018

Pages :   241-243

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization of Benzimidazole Derivatives carrying Pyridine Moiety



Address:   K. Durga Prasad1, M. Sandhya Rani2*, D. Anusha2
1Natco Research Centre, Sanath Nagar, Hyderabad-500018
2Department of Pharmaceutical Chemistry, Pulla Reddy Institute of Pharmacy,
Gummadidala, Sangareddy, Telangana-502110
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00045.7

ABSTRACT:
A new series of 1-methyl-2{[(3,4,5- tri substituted pyridine2-yl) methyl] sulfanyl}-5-nitro-1H-benzimidazoles 3a-3b were synthesized by coupling 1-methyl-2-mercapto-5-nitro-1H-benzimidazole 1 with various pyridine derivatives 2a-2b in the presence of a base at room temperature, Upon further oxidation of these Benzimidazole derivatives 3a-3b in presence of MCPBA gives 1-methyl-2{[(3,4,5- tri substituted pyridine2-yl) methyl] sulfinyl}-5-nitro-1H-benzimidazoles 4a-4b. The group frequencies of IR and NMR spectra were assigned.
KEYWORDS:
1-methyl-2-mercapto-5-nitro-1H-benzimidazole, pyridine derivatives, MCPBA, coupling, IPE.
Cite:
K. Durga Prasad, M. Sandhya Rani, D. Anusha. Synthesis, Characterization of Benzimidazole Derivatives carrying Pyridine Moiety. Asian J. Research Chem. 2018; 11(2):241-243.
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