Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  2

Year :  2018

Pages :   505-508

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Review of Heterocyclic Scaffolds for the Inhibitors of ATP synthase



Address:   Saurabh Mehta*
Department of Applied Chemistry, Delhi Technological University, Bawana Road, Delhi, 110042 India
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00090.1

ABSTRACT:
ATP synthase is an important enzyme and is an established drug target. The involvement of this enzyme has been attributed to various serious diseases and physiological conditions, such as cancer, obesity, neurodegenerative disorders, etc. It makes it an attractive drug target whose activity may be modulated by small molecules. A variety of inhibitors reported in the literature have been reviewed, and the important O- and N- containing heterocyclic scaffolds have been identified and are presented here. On examining the scaffolds, it is observed that a variety of 5-membered ring containing compounds to macrocycles inhibit ATP synthase. These include Flavones and Isoflavons, Catechins, Estrogen metabolites, Polyenic ?-pyrones, Amphiphilic cationic dyes, Tertiary amine local anesthetics (TALAs), N-sulfonyl tetrahydrobenzodiazepines, N-[1-Aryl-2-(1-imidazolo)ethyl]-acylguanidine derivatives, O-[1-Aryl-2-(1-imidazolo)ethyl]-thiourethane derivatives and 4-amino benzopyrans.
KEYWORDS:
ATP synthase, Drug Discovery, Enzyme, Heterocycle, Inhibitor..
Cite:
Saurabh Mehta. Review of Heterocyclic Scaffolds for the Inhibitors of ATP synthase. Asian J. Research Chem. 2018; 11(2):505-508.
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