Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  2

Year :  2018

Pages :   509-512

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Evaluation of Some Phenothiazine Derivatives



Address:   Pooja Saini1*, Pankaj Baboo2
1 IIMT College of Medical Sciences, Meerut, U.P.-250001
2Radha Govind Institute Of Pharmacy, Moradabad, U.P.-244001
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00091.3

ABSTRACT:
Phenothiazine is an aromatic heterocyclic compound, used as tricyclic anti psychotic drugs. Synthesis of phenothiazine was started in the year 1883. In early era phenothiazine used as dye cellulose and fibers. But as a drug phenothiazine was focused in 1950s, as 10-substituted derivatives. Along with this phenothiazine also has antiseptic, anti helminthes, and insecticidal effect. Most prominent use of these derivatives is as tranquilizer because it has defused anti psychotic effect . It is also reported to have anti cancer, antitubercular, anti-inflammatory, anticonvulsant, anthelmintic, analgesic and antiviral effects. The biological evaluation for the CNS depressant activity has been performed. From the biological investigation, it is found that out of all the synthesized two compounds show potent CNS depressant activity.
KEYWORDS:
Phenothiazine, Heterocyclic compound, CNS depressant activity.
Cite:
Pooja Saini, Pankaj Baboo. Synthesis and Biological Evaluation of Some Phenothiazine Derivatives,. Asian J. Research Chem. 2018; 11(2):509-512.
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