Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  3

Year :  2018

Pages :   585-587

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Methodology Study and a Practical, Cost Efficient Synthesis of a 3-(2-Methyl-1-oxo-indan-2-ylmethyl)-isochromen-1-one



Address:   S. Shiva Rama Krishna*1 and R. Sreenivasulu2
*1Research Scholar, Mewar University, Rajasthan, India
2Research Supervisor, Mewar University, Rajasthan, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00104.9

ABSTRACT:
1-Oxo-1H-isochromene-3-carbaldehyde (1) reacts with Indan-1-one (2) to offer 4-(1-Oxo-indan-2-ylidenemethyl)-isochromen-1-one (3) which on reaction with liquid ammonia produces 3-(1-Oxo-indan-2-ylmethyl)-isochromen-1-one (4). Compound 4 is reduced with LDA to 3-(2-Methyl-1-oxo-indan-2-ylmethyl)-isochromen-1-one (5). The structures of the compounds are confirmed by spectral data.
KEYWORDS:
Coumarins, anticoagulant, anti-inflammatory.
Cite:
S. Shiva Rama Krishna and R. Sreenivasulu. Methodology Study and a Practical, Cost Efficient Synthesis of a 3-(2-Methyl-1-oxo-indan-2-ylmethyl)-isochromen-1-one. Asian J. Research Chem. 2018; 11(3):585-587.
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