Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  3

Year :  2018

Pages :   671-680

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Absolute Configuration of Boceprevir Chiral fragment-B by Chiral Chromatographic, Spectroscopic, Thermal and Crystallization Techniques



Address:   Nagaraju Rajana1,3* ,V. Pallavi1, P. Madhavan1, H. Rama Mohan1,J. Moses Babu2,K. Basavaiah3
1Technology Development Center, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Ltd, Miyapur, Hyderabad 500049, India,
2Integrated Product Development Organization, Dr. Reddy’s Laboratories, Innovation Plaza, Bachupally, Telangana 500072, India,
3Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam (AP),530003 India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00120.7

ABSTRACT:
During reverse phase chromatography, the chiral fragment–B of Boceprevir i.e methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride was separated along its cis isomer, acid impurity and ester impurity. The R and S isomers of Trans isomers were separated by chiral chromatography; the chiral S isomer was characterized by the 1D NMR, FT-IR, Mass, SOR, X ray studies and differential scanning colorimetry.
KEYWORDS:
Boceprevir, Absolute configuration, 1D NMR, Chiral chromatography
Cite:
Nagaraju Rajana , V. Pallavi, P. Madhavan, H. Rama Mohan, J. Moses Babu, K. Basavaiah. Absolute Configuration of Boceprevir Chiral fragment-B by Chiral Chromatographic, Spectroscopic, Thermal and Crystallization Techniques. Asian J.Research Chem. 2018; 11(3): 671-680.
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