Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  3

Year :  2018

Pages :   539-544

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Isolation and Structure Characterization of related impurity in Olanzapine key starting material by LC/ESI-MS and NMR



Address:   Jagadeesh Narkedimilli1,2*, Vishweshwar Vavilala1, Sandeep Mohanty1, Saravanan Manvalan1, Jayashree Anireddy2
1Dr. Reddy’s Laboratories Limited, API Plant, Bollaram-III, Plot No 116, IDA Bollaram, Medak District, Hyderabad 502325, Telangana, India.
2Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Kukatpally, Hyderabad 500085, Telangana, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00096.2

ABSTRACT:
Olanzapine key starting material, 5-methyl-2-((2-nitrophenyl)amino)thiophene-3-carbonitrile (3), is a key starting material of Olanzapine. During the impurity profile study an unknown peak was detected by HPLC and MS methods. Identification, isolation and structural characterization in olanzapine key starting material is described in this article. The impurity was isolated by preparative HPLC, Based on the complete spectral analysis, MS, 1D NMR (1H and 13C) and 2D NMR (COSY, HSQC and HMBC) the chemical structure of unknown impurity was characterized as 2-(bis(2-nitrophenyl)amino)-5-methylthiophene-3-carbonitrile.
KEYWORDS:
Liquid chromatography-mass spectrometry, NMR, Characterization, impurity profile, Olanzapine.
Cite:
Jagadeesh Narkedimilli, Vishweshwar Vavilala, Sandeep Mohanty, Saravanan Manvalan, Jayashree Anireddy. Isolation and Structure Characterization of related impurity in Olanzapine key starting material by LC/ESI-MS and NMR. Asian J. Research Chem. 2018; 11(3):539-544.
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