Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  4

Year :  2018

Pages :   723-730

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterisation, Biological and Molecular Docking Studies of Aconitic Acid Based Co-Polyester



Address:   Vanitha Krishna Kumar, Mrs.NanthiniRaveendiran
Postgraduate and Research Department of Chemistry, Pachaiyappa’s College, University of Madras, Chennai, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00128.1

ABSTRACT:
Aliphatic polyester elastomers are class of biomaterials that are widely used for drug delivery and tissue engineering. The demand for biodegradable non toxic elastomers is ever increasing due to their dexterity of being biocompatible and biodegradable. A series of novel biodegradable polyesters are synthesised, using multifunctional non- toxic monomers: aconitic acid, citric acid, sebacic acid and glycerol by melt condensation method, followed by post polymerisation. The chemical structure of the elastomer arecharacterised by FT-IR, 1H NMR and 13C NMR.TGA, and DSC techniques are used to determine the physical properties of the polymers. The low Tg values and a higher Tm and Td illustrates the elasticity and stability of the synthesised elastomers respectively which makes it suitableas implant materials.The CAM assay exhibits the wound healing property which is further confirmed by the molecular docking with the matrix metalloproteinase.Chorioallantoic membrane (CAM) assay shows that the formation of blood vessels is 178% and 169% greater than the standard. Lib dock score of these polymers with MMP2, MMP8and MMP12 suggests that are effective MMP inhibitors. The observed results unambiguously suggest that the synthesized elastomer poly(glycerol acotinate-co-glycerol citrate)PACGLand poly(glycerol acotinate-co-glycerol sebacate)PASGL have excellent wound healing abilityand are suitable aspotent biomaterials in the biomedical field.
KEYWORDS:
Elastomer, Aconitic acid, Molecular docking, CAM assay, Implant biomaterial.
Cite:
Vanitha Krishna Kumar, .NanthiniRaveendiran. Synthesis, Characterisation, Biological and Molecular Docking Studies of Aconitic Acid Based Co-Polyester. Asian J. Research Chem. 2018; 11(4):723-730.
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