Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  4

Year :  2018

Pages :   739-745

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones

Address:   Srishyalam. Vadde 1, Devanna. N1, Shiva Rama Krishna. S2, Sreenivasulu R2, Naveen Mulakayala3
1Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.
2Mewar University, Gangrar, Chittorgarh, Rajasthan-312901
3Clearsynth Labs Ltd. IDA Mallapur, Nacharam, Hyderabad-500076, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2018.00130.X

A simple, convenient and efficient method for the synthesis of 5-aryl/alkyl pyrazolo[4,3-d]pyrimidin-7(6H)-ones from 4-amino-1-methyl-3-propylpyrazole-5-carboxamide by the condensation of aldehydes under mild and neutral reaction conditions using N-bromosuccinamide (NBS)as oxidantwith good yields and high selectivity in single step which have potential applications in medicinal chemistry.
pyrazolo[4,3-d]pyrimidin-7(6H)-ones, N-Bromosuccinamide and metal free oxidative cyclisation
Srishyalam. Vadde , Devanna. N, Shiva Rama Krishna. S, Sreenivasulu R, Naveen Mulakayala. N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones. Asian J. Research Chem. 2018; 11(4):739-745.
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