Journal :   Asian Journal of Research in Chemistry

Volume No. :   11

Issue No. :  6

Year :  2018

Pages :   876-886

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Review Report on Active Methylene group in Malononitrile

Address:   Suman Kumari1, Vinita Gupta2, Sanchita Singh3, Y.K. Gupta4* 1Research Scholar, School of Applied Sciences Singhania University Pacheri Bari, Jhunjhunu (Raj.), India
2Department of Chemistry, Agra College, Agra, U.P, India
3Department of Chemistry, Agra College, Agra, U.P, India
4Head Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, India
*Corresponding Author E-mail:
DOI No: 10.5958/0974-4150.2018.00153.0

The Knoevenagel condensation is a kind of nucleophilic addition reaction which is used to convert an aldehyde or ketone and an activated methylene to a substituted olefin using an amine base as a catalyst. The reaction begins by deprotonation of the activated methylene by the base to give a resonance stabilized enolate. The amine catalyst also reacts with the aldehyde or ketone to form an iminium ion intermediate, which then gets attacked by the enolate. The intermediate compound formed gets deprotonated by the base to give another enolate while the amine of the intermediate gets protonated. A rearrangement then ensues which releases the amine base, regenerates the catalyst, and yields the final olefin product. In present papera versatile function of malononitrile in the development of organic synthesis and their new result are explored. The active methylene group of malononitriles is very important attacking part in the heterocyclic conversions and also having a great influence towards several antimicrobial Activities.
Malononitrile, antimicrobial Activities, Active methylene group in malononitrile.
Suman Kumari, Vinita Gupta, Sanchita Singh3, Y.K. Gupta. A Review Report on Active Methylene group in Malononitrile. Asian J. Research Chem. 2018; 11(6):876-886.
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