Journal :   Asian Journal of Research in Chemistry

Volume No. :   12

Issue No. :  1

Year :  2019

Pages :   41-45

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Green and Environmentally Friendly, An Improved Synthesis of Pimavanserin (5-HT2A Receptor)

Address:   Rajesh Kumar Rapolu1, 2, V.V.N.K.V. Prasada Raju1, Murthy Chavali2, Naveen Mulakayala3
1Granules India Limited – R & D Center, Plot No.56, Road No.5, ALEAP Industrial Area, Pragathinagar, Hyderabad, 5000072, India
2Division of Chemistry, Department of Science and Humanities, Vignan's Foundation for Science Technology and Research University (VFSTRU), Vadlamudi, Guntur 522 213, India
3SVAK Life Sciences, ALEAP Industrial Area, Pragathi Nagar, Hyderabad 500090, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2019.00010.5

Water mediated and environmentally friendly, step-wise an improved synthesis of pimavanserin have been developed from the key intermediate of 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methyl piperidin-4-yl) thiourea at different solvent conditions. These reactions have an easy workup; provide good to excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign and no need of column chromatography for product isolation.
Pimavanserin, Parkinson disease, Nuplazid, dopamine receptor
Rajesh Kumar Rapolu, V.V.N.K.V. Prasada Raju, Murthy Chavali, Naveen Mulakayala. A Green and Environmentally Friendly, An Improved Synthesis of Pimavanserin (5-HT2A Receptor). Asian J. Research Chem. 2019; 12(1): 41-45.
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