Journal :   Asian Journal of Research in Chemistry

Volume No. :   12

Issue No. :  1

Year :  2019

Pages :   07-10

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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UV Spectrophotometric Method for Estimation of Sacubitril in Synthetic Mixture



Address:   Leela Madhuri P, Hemant Kumar T*, Srinivasa Rao Y, Vara Prasada Rao K
Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institute of Pharmaceutical Technology Beside VSEZ, Duvvada, Visakhapatnam-530049
*Corresponding Author
DOI No: 10.5958/0974-4150.2019.00002.6

ABSTRACT:
This paper describes a simple, accurate, specific and sensitive UV spectrophotometric method for determination of Sacubitril in synthetic mixture. A study was carried out of the parameters established as per ICH guide lines to validate an analytical method i.e. linearity, range, accuracy, precision and sensitivity. A wavelength maximum of Sacubitril in methanol and water (25:75 v/v) was selected at 242 nm. Method was found to be linear in the range of 2-12 µg/ml with a correlation coefficient (r) of 0.999. Method was successfully validated as per ICH guidelines. In addition, this proposed method was simple, sensitive, and easy to apply and requires relatively inexpensive instruments.
KEYWORDS:
Sacubitril, Methanol, Synthetic mixture, UV Spectrophotometric method.
Cite:
Leela Madhuri P, Hemant Kumar T, Srinivasa Rao Y, Vara Prasada Rao K. UV Spectrophotometric Method for Estimation of Sacubitril in Synthetic Mixture. Asian J. Research Chem. 2019; 12(1): 07-10.
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