Journal :   Asian Journal of Research in Chemistry

Volume No. :   12

Issue No. :  1

Year :  2019

Pages :   25-28

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages



Address:   Rajan V. Rele*
Department of Chemistry, D. G. Ruparel College, Mahim, Mumbai 400016.
*Corresponding Author
DOI No: 10.5958/0974-4150.2019.00006.3

ABSTRACT:
A sensitive non-aqueous potentiometric titration method was developed for quantitative determination of secnidazole from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2> 0.999) between 20 % to 100 % of 500 mg of drug substance weight. The percentage recovery of secnidazole in the optimized method was between 99.643 to 100.505 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
KEYWORDS:
Secnidazole, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.
Cite:
Rajan V. Rele. A non-Aqueous Potentiometric Titration Method for Validation of Secnidazole from Pharmaceutical Dosages. Asian J. Research Chem. 2019; 12(1): 25-28.
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