Journal :   Asian Journal of Research in Chemistry

Volume No. :   12

Issue No. :  2

Year :  2019

Pages :   112-115

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of UV Spectrophotometric Method for Estimation of Cyproheptadine hydrochloride



Address:   Prof. Sushil D. Patil*, Tejashri Dugaje*, Dr. Sanjay J. Kshirsagar
MET’s Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik,
Savitribai Phule Pune University, Maharashtra, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2019.00024.5

ABSTRACT:
A new, simple, accurate and sensitive UV –spectrophotometric absorption correction method has been developed for estimation of cyproheptadine hydrochloride in bulk utilizing concept of standard addition. The method is based upon determination of cyproheptadine hydrochloride at 286nm, distilled water as a solvent. Linearity was observed in range of 2-10ug/ml for cyproheptadine hydrochloride. The correction coefficient value was found to near to1. All validation methods were validated as per ICH guideline.
KEYWORDS:
Cyproheptadine HCl, UV-spectrophotometric, Method Development and Validation as per ICH guideline.
Cite:
Sushil D. Patil, Tejashri Dugaje, Sanjay J. Kshirsagar. Development and Validation of UV Spectrophotometric Method for Estimation of Cyproheptadine hydrochloride. Asian J. Research Chem. 2019; 12(2):112-115.
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