Journal :   Asian Journal of Research in Chemistry

Volume No. :   12

Issue No. :  2

Year :  2019

Pages :   116-119

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis, Characterization and Antimicrobial Screening of Some Novel Chromonyl Isoxazoles



Address:   Dr. V. P. Sharma1, Dr. Rakesh Kumar2*
1Department of Chemistry, Meerut College, Meerut (UP) India
2Department of Chemistry, M.M.M. (P.G.) College, Bhatpar Rani, Deoria (UP) India
*Corresponding Author
DOI No: 10.5958/0974-4150.2019.00025.7

ABSTRACT:
Isoxazolines and chromones are one of the active class of the compounds possessing a wide range of biological and medicinal activities. In this publication, the synthesized some novel compounds containing chromone as well as Isoxazoline moiety together is being studied systematically. The synthesis of 5-(2’-Aryl/heteroaryl chromon-6’-yl)-3-aryl/heteroaryl isoxazoles [II(a-b)] by the condensation of 1-(2’-aryl/furyl chromon-6’-yl)-3-aryl or heteroarylprop-2-en-1-ones [I(a-f)] with hydroxylamine hydrochloride. The synthesized compounds have been characterized by elemental analysis, FT-IR and PMR spectral data. The synthesized compounds have been evaluated for their antibacterial and antifungal activities. Most of the compounds have been found moderately active when compared with the reference standard drugs.
KEYWORDS:
Chromone, Chalcone, Hydroxylamine Hydrochloride, Antifungal and Antibacterial Activity.
Cite:
V. P. Sharma, Rakesh Kumar. Synthesis, Characterization and Antimicrobial Screening of Some Novel Chromonyl Isoxazoles. Asian J. Research Chem. 2019; 12(2):116-119.
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