Journal :   Asian Journal of Research in Chemistry

Volume No. :   12

Issue No. :  2

Year :  2019

Pages :   55-57

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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An Efficient andNovel Synthesis of Pregabalin with Enantioselective Enzymatic Hydrolysis using CAL-B Enzyme



Address:   Kishore Gokavarapu1*, Rahul Uttamrao Devkar1, Sarita Gokavarapu3, Shiva Rama Krishna Samala2, Durga Prasad Rao3
1Production Department-Helios Lifesciences Limited, 79 and 100, Industrial Growth Center, Malanpur, District: Bhind, MP–477117
2 Research and Development Department–Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117
3QC and ADL Department–Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117
*Corresponding Author
DOI No: 10.5958/0974-4150.2019.00012.9

ABSTRACT:
The present paper describes the CAL-B (Enzymatic) desmmetrization of Prochiral Dimethyl 3-Isobutylpentanedioate was performed to prepare optically active (S)-3-(2-methoxy2-oxoethyl)-5-methylhexanoic acid. Based on this reaction, the synthesis of (S)-(+)-3-aminomethyl-5-methylhexanoic acid (S-Pregabalin) was achieved with a 70-75% overall yield.
KEYWORDS:
Pregabalin, CAL-B, Enantioselective, Enzyme, Hydrolysis.
Cite:
Kishore Gokavarapu, Rahul Uttamrao Devkar, Sarita Gokavarapu, Shiva Rama Krishna Samala, Durga Prasad Rao. An Efficient and Novel Synthesis of Pregabalin with Enantioselective Enzymatic Hydrolysis using CAL-B Enzyme. Asian J. Research Chem. 2019; 12(2):55-57.
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