Journal :   Asian Journal of Research in Chemistry

Volume No. :   12

Issue No. :  2

Year :  2019

Pages :   58-62

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Designing and Synthesis of some Novel 2-Substituted Benzimidazole Derivatives and their Evaluation for Antimicrobial and Anthelmintic Activity



Address:   Chaitanya Prasad Meher*, Abinash Kumar Sahu, Srimanta Kumar Dash, Ranjan Kumar Sahoo, Subodha Chandra Sahu, Dillip Kumar Gupta
Department of Pharmaceutical Chemistry, The Pharmaceutical College (TPC), Tingipali, Barpali, Odisha
*Corresponding Author
DOI No: 10.5958/0974-4150.2019.00013.0

ABSTRACT:
Objective: To design, synthesis & evaluation of 2-substituted benzimidazole derivatives for antimicrobial & anthelmintic activity. Method: The presented investigation is designed to upgrading the modest and comfortable method for development of numerous 2-substituted benzimidazole derivatives. It involves reaction of different derivatives of benzaldehyde with the benzimidazole. The synthesized compounds were subjected to software chem sketch, Molinspiration and FTIR. The synthesized compounds were investigated for antimicrobial activity by minimum inhibitory concentration & zone of inhibition method while anthelmintic activity by using Pheretima posthuma. Result: The 2-substituted benzimidazole derivatives were synthesized by unadventurous method. All the synthesized compounds displayed a characteristic peak in FTIR. It was found that the synthesized compounds showed appreciable antimicrobial as well as anthelmintic activity. Conclusion: It manifest a preferable synthetic procedure for benzimidazole derivatives which may attract the scientist in future for generation of newer antimicrobial & anthelmintic medication.
KEYWORDS:
Heterocyclic compound, Antimicrobial, Interpretation, Pharmacology.
Cite:
Chaitanya Prasad Meher, Abinash Kumar Sahu, Srimanta Kumar Dash, Ranjan Kumar Sahoo, Subodha Chandra Sahu, Dillip Kumar Gupta. Designing and Synthesis of some Novel 2-Substituted Benzimidazole Derivatives and their Evaluation for Antimicrobial and Anthelmintic Activity. Asian J. Research Chem. 2019; 12(2):58-62.
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