Journal :   Asian Journal of Research in Chemistry

Volume No. :   12

Issue No. :  6

Year :  2019

Pages :   317-321

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Multi Component Reactions (MCR): Nano ZnO catalysed efficient synthesis of Novel Thiazolidinones



Address:   Bandaru Devi, B. Madhavi, G. Veera Raghava Sharma*
Department of Chemistry, GITAM Institute of Science , GITAM (Deemed to be University), Rushikonda, Visakhapatnam 530045, AP, India
*Corresponding Author
DOI No: 10.5958/0974-4150.2019.00058.0

ABSTRACT:
Nano ZnO has shown to be a suitable catalyst in a multicomponent reaction involving an aldehyde, an amine, and thioglycolic acid in N,N-dimethylformamide at moderate temperature (50°C) to form thiazolidinones. This one-pot method involved reasonable reaction time, easy workup and purification procedure to furnish products in excellent yields. In particular, campholenic aldehyde obtained from a-pinene was used to synthesize medicinally useful bioactive thiazolidinones. Products were characterized by IR, 1H NMR, 2DNMR and mass spectra.
KEYWORDS:
Nano ZnO, thiazolidinones, multi component reaction (MCR), moderate conditions, easy workup and purification.
Cite:
Bandaru Devi, B. Madhavi, G. Veera Raghava Sharma. Multi Component Reactions (MCR): Nano ZnO catalysed efficient synthesis of Novel Thiazolidinones. Asian J. Research Chem. 2019; 12(6):317-321.
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