Journal :   Asian Journal of Research in Chemistry

Volume No. :   13

Issue No. :  1

Year :  2020

Pages :   52-59

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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In vitro and Molecular Docking Studies of DPPH with Phoenix dactylifera L. (Deglet-Nour) Crude Fruits extracts and Evaluation of their Antioxidant Activity



Address:   Samir Zeroual1*, Ismail Daoud 2,3, Randa Gaouaoui1, Said Ghalem3
1Laboratory of Genetics, Biotechnology and Valorization of Bio-resources, Department of Nature Sciences and the Life, Faculty of Exact Sciences and Nature Sciences and the Life, University Mohamed Khider, Biskra, Algeria
2University Mohamed Khider, Department of Matter Sciences, BP 145 RP
(07000) Biskra, Algeria.
3Laboratory of Natural and Bio-actives Substances. Tlemcen University- Faculty of Science. P.O. Box 119-Tlemcen-Algeria.
*Corresponding Author
DOI No: 10.5958/0974-4150.2020.00012.7

ABSTRACT:
Uses edible parts of date palm (Phoenix dactylifera L) fruits from Algeria were analyzed to determine their phenolic compound and antioxidant activities using DPPH, FRAP assay and molecular docking. In this paper, in-silico and in-vitro studies were used to study interaction Enzyme-Compounds and evaluate antioxidant activities of compounds. The results show that the date fruit rich in the total phenolic content was found Gallic acid, the flavonoid: quercetin and condensed tannins of catechin. The antioxidant activity ranged between 64, 46-91, 3 for DPPH (%) and 0,194-14,923µg AAE/ 0.5mg extract for FRAP. In-silico analysis was an agreement with in-vitro in which phenolic compounds showed more negative free energy against standard drug and bound with catalytic residues of Kinase. The findings provide evidence that date fruit has potential as a natural source of antioxidant with ethyl acetate showing to be the best extracting with corresponding higher antioxidant activities.
KEYWORDS:
Algerian date palm fruit, Antioxidant activity, Synthesis, DPPH, Molecular docking.
Cite:
Samir Zeroual, Ismail Daoud, Randa Gaouaoui, Said Ghalem. In vitro and Molecular Docking Studies of DPPH with Phoenix dactylifera L. (Deglet-Nour) Crude Fruits extracts and Evaluation of their Antioxidant Activity; Asian J. Research Chem. 2020; 13(1): 52-59.
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