Journal :   Asian Journal of Research in Chemistry

Volume No. :   13

Issue No. :  2

Year :  2020

Pages :   82-84

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Validated Non-aqueous Potentiometric Titration Method for Quantitative Determination of Terbutaline Sulphate from Pharmaceutical Preparation



Address:   Rele Rajan V, Tiwatane Prathamesh P.
Central Research Laboratory, D.G. Ruparel College, Mahim, Mumbai, 400016
*Corresponding Author
DOI No: 10.5958/0974-4150.2020.00017.6

ABSTRACT:
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of terbutaline sulphate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 50 % to 150 % of 0.400 mg of drug substance weight. The percentage recovery of terbutaline sulphate in the optimized method was between 99.39 to 99.64 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
KEYWORDS:
Terbutaline sulphate, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid mercury acetate.
Cite:
Rele Rajan V, Tiwatane Prathamesh P. A Validated Non-aqueous Potentiometric Titration Method for Quantitative Determination of Terbutaline Sulphate from Pharmaceutical Preparation Asian J. Research Chem. 2020; 13(2):82-84.
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