Journal :   Asian Journal of Research in Chemistry

Volume No. :   13

Issue No. :  2

Year :  2020

Pages :   109-112

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of RP-HPLC Method of Gabapentin in Pure and Pharmaceutical Formulations



Address:   Dilip Chandak, Pushpendra Sharma
Department of Chemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001, Madhya Pradesh, India.
*Corresponding Author
DOI No: 10.5958/0974-4150.2020.00022.X

ABSTRACT:
A validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Gabapentin in pure and pharmaceutical formulations. Method was carried on Zodiac C18 column (250 mm × 4.6 mm × 5µ particle size) using Methanol: Acetonitrile: Triethylamine (50: 25: 25) as mobile phase. Detection was carried out by U.V. at 211nm. The proposed method obeyed linearity in the range of 10-60µg/mL. and met all specifications as per ICH guidelines. Statistical analysis revealed that this method can be used in routine quality control studies of Gabapentin in pure and its formulations.
KEYWORDS:
Gabapentin, C18 column, Reverse phase, Validation, Specificity.
Cite:
Dilip Chandak, Pushpendra Sharma. Department of Chemistry, Sri Satya Sai University of Technology & Medical Sciences, Sehore-466001, Madhya Pradesh, India. Asian J. Research Chem. 2020; 13(2):109-112.
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