Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  8

Year :  2012

Pages :   1074-1077

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Validated Eco - Friendly Derivative Spectrophotometric Method for Valsartan and Hydrochlorothiazide Combined Tablet Dosage Form



Address:   Haripriya A.*, Sirisha N., Vishali S., Ramakrishna K., Panikumar A.D.
Department of Pharmaceutical Analysis and Quality Assurance, Gokaraju Rangaraju College of Pharmacy, Osmania University, Hyderabad-90
*Corresponding Author
DOI No:

ABSTRACT:
Now a day’s hydrotropic agents are using for development of new analytical method for quantification of poorly water soluble drugs by enhancement of it’s solubility. In the present investigation, 0.01M sodium citrate solution was employed as hydrotropic solubilising agent to solubilise poorly water soluble drugs such as valsartan (VAL) and hydrochlorothiazide (HCZ) bulk drug as well as its combined dosage form for its derivative spectrophotometric analysis in ultra violet region. Two wavelengths i.e. 271.9nm (zero crossing point for HCZ) and 333nm (zero crossing point for VAL) were selected for the estimation of VAL and HCZ respectively, using 0.01M sodium citrate as solvent. The hydrotropic solution used did not show any absorbance at above 250nm, and therefore, no interference in the estimation was seen. Results of analysis were statistically validated for linearity, precision, accuracy and sensitivity. The proposed method is new, simple, eco-friendly, cost effective and can be successfully employed in routine to analyze various pharmaceutical dosage forms, precluding the use of organic solvents(which are pollutants, toxic, costlier and give error due to volatility).
KEYWORDS:
Eco-friendly, Hydrotropy, Sodium citrate, Valsartan, Hydrochlorothiazide
Cite:
Haripriya A., Sirisha N., Vishali S., Ramakrishna K., Panikumar A.D.. Validated Eco - Friendly Derivative Spectrophotometric Method for Valsartan and Hydrochlorothiazide Combined Tablet Dosage Form. Asian J. Research Chem. 5(8): August, 2012; Page 1074-1077.
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