Karunakaran Sulochana Meena, Thyagarajan Venkataraman, Prakasa Rao Aruna, Singaravel Ganesan
Karunakaran Sulochana Meena1, Thyagarajan Venkataraman3, Prakasa Rao Aruna2 and Singaravel Ganesan2
1Department of Chemistry, Queen Mary’s College, Chennai
2Department of Physics, Anna University, Chennai
3Department of Chemistry, Adhiparasakthi College of Science, Kalavai
Volume - 4,
Issue - 3,
Year - 2011
Core-shell type nanoparticles namely Ag@TiO2 and Au@TiO2 were prepared by one pot simultaneous reduction of HAuCl4 and hydrolysis of Ti(IV) isopropoxide. They were characterized by absorption and fluorescence spectroscopy, XRD, HR-TEM and AFM techniques. XRD patterns show the presence of anatase form of TiO2 and the noble metals. Since the catalytic properties of the oxide surfaces modified with the metal core especially photo catalysis is an important aspect and considering the fact that erythrocytes serve as model cells to the molecular mechanism of PDT, the photohemolysis was studied using these core-shell type NPs viz. Ag@TiO2 and Au@TiO2. Their photodynamic activities were compared. The effect of scavengers viz., GSH and NaN3 showed that there is a considerable amount of reactive oxygen species formation which are responsible for cell death. The detailed mechanism has been discussed.
Cite this article:
Karunakaran Sulochana Meena, Thyagarajan Venkataraman, Prakasa Rao Aruna, Singaravel Ganesan.Comparison of Photodynamic Activities of Ag@Tio2 and Au@Tio2 Core – Shell Nanoparticles in Human Erythrocytes. Asian J. Research Chem. 4(3): March 2011; Page 387-391.