Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja
Prathima Patil*, S.P. Sethy, T. Sameena, K. Shailaja
Department of Medicinal Chemistry, Sushrut Institute of Pharmacy,
Tadanpally (v), Pulkal(m), Medak Dist-754202
Volume - 6,
Issue - 10,
Year - 2013
Pyridine is a planer Six-member heterocyclic ring with 5C and 1N atom and in ring N is present in 1st and positions. The Pyridine ring is a constituent of several important natural products, including niconine, nicotine, and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. Pyridine derivatives have occupied a unique place in the field of medicinal chemistry. The incorporation of the pyridine nucleus is an important synthetic strategy in drug discovery. The high therapeutic properties of the Pyridine related drugs have encouraged the medicinal chemists to synthesize a larger number of novel chemotherapeutic agents. Pyridine drugs have broadened scope in remedying various dispositions in Clinical medicines. Numerous methods for the synthesis of Pyridine and also their various structure reactions offer enormous scope in the field of medicinal chemistry. This articles aims to review the work reported, their chemistry and biological activities of Pyridine during past years.
Cite this article:
Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja. Pyridine and Its Biological Activity: A Review. Asian J. Research Chem. 6(10): October 2013; Page 888-899.