ABSTRACT:
Glimepiride, a third-generation sulfonylurea, is a commonly used oral antidiabetic medication, but has extremely low aqueous solubility, thus complicating its determination by routine methods of solvent-free or environmentally benign antidiabetic methods. The traditional UV and high-performance liquid chromatography (HPLC) methods are highly dependent on the use of toxic organic solvents, including methanol, acetonitrile, and chloroform that leads to the generation of a high level of chemical waste and increases the risks of laboratory accidents. The growing discipline of green analytical chemistry fosters sustainable, low-hazard and environmentally efficient analytical procedures, which encourages seeking greener alternatives to the traditional solvent-based analyses. The aim of green analytical chemistry is to develop methods that minimize their effect on the environment without interfering with the performance of the analysis. In this context, hydrotropic solubilization has risen as one of the promising solutions, since it increases the solubility of poorly water-soluble drugs by using safe, inexpensive, and non-toxic hydrotropes, such as sodium benzoate, urea, sodium citrate and mixtures of hydrotropic systems.Hydrotropy improves the solubility based on non-micellar aggregation, disruption of water-structure, p-p, and hydrogen bonding, allowing the solubility to be significantly increased without the use of organic solvents. In the case of Glimepiride, recent research has shown that outstanding improvements in solubility and dissolution occurred with hydrotropic systems and hydrotropic solid dispersions, which shows high potential in developing the green UV-visible analysis. Four comprehensive tables quantify hydrotropic performance: Table 1 shows >13,000x solubility enhancement with urea (49.51 µg/ml vs 3.8 µg/ml water), Table 2 validates five methods (LOD 0.01-1.0 µg/ml, R²>0.999), while Tables 3-4 demonstrate superior greenness with Eco-scale 85 and GAPI 96% green zones vs 32% for conventional HPLC. Hydrotropic UV eliminates organic solvents, reduces waste 93%, and matches analytical performance of traditional methods.
Cite this article:
Yadav Sameer R., Bhagwat Avinash M.. Green Hydrotropic Analytical Approaches for Glimepiride: A Comprehensive Review of Methods, Mechanisms, and Greenness Metrics. Asian Journal of Research in Chemistry.2026; 19(4):347-6. doi: 10.52711/0974-4150.2026.00053
Cite(Electronic):
Yadav Sameer R., Bhagwat Avinash M.. Green Hydrotropic Analytical Approaches for Glimepiride: A Comprehensive Review of Methods, Mechanisms, and Greenness Metrics. Asian Journal of Research in Chemistry.2026; 19(4):347-6. doi: 10.52711/0974-4150.2026.00053 Available on: https://ajrconline.org/AbstractView.aspx?PID=2026-19-4-10