ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): G. Venkannaa, G. Madhusudhan, K. Mukkanti, Y. Sampath Kumar

Email(s): madhusudhan.gutta@yahoo.com

DOI: 10.5958/0974-4150.2015.00051.6   

Address: G. Venkannaa2, G. Madhusudhan1*, K. Mukkanti2, Y. Sampath Kumar1
1Department of Research and Development, Inogent Laboratories Private Limited (A GVK BIO Company), 28A, IDA, Nacharam, Hyderabad 500 076, India
2Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500 072, India
*Corresponding Author

Published In:   Volume - 8,      Issue - 5,     Year - 2015


ABSTRACT:
During the preparation of ethyl 4-(1-Hydroxy-1-methylethyl)-2-propylimidazole- 5-carboxylate (1), derivative, eleven related substances (Impurities and analog) were observed along with the final Imidazole derivative. Those impurities were identified as, Ethyl carbinol imidazole (13), Methoxy imidazole (14), Olefinic imidazole (15), 4-Acetyl imidazole (12), Diacetyl imidazole (16), 5-Acetyl imidazole (17), Diethyl ester imidazole (9), Acetate imidazole Impurity (23), Propionate imidazole Impurity (29), Isobutyrate Imidazole Impurity (41) and butyl Imidazole Impurity (35). Present work describes the synthesis and characterization of all these elven impurities.


Cite this article:
G. Venkannaa, G. Madhusudhan, K. Mukkanti, Y. Sampath Kumar. Identification synthesis of process-related impurities (substances) ethyl-4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate [key intermediate of Olmesartan medoxomil (Anti hypertensive drug)]. Asian J. Research Chem 8(5): May 2015; Page 307-317. doi: 10.5958/0974-4150.2015.00051.6


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